Login

Forgot your password?
New User?
Remember me
banner banner

You are here:Home » Antibodies » Abs to Transport Proteins » Anti -Zinc Transporter ZIP2 (Solute Carrier Family 39 Member 2, Zrt- and Irt-like Protein 2, ZIP-2, hZIP2, SLC39A2, 6A1, Eti-1, ZIP2)

Anti -Zinc Transporter ZIP2 (Solute Carrier Family 39 Member 2, Zrt- and Irt-like Protein
2, ZIP-2, hZIP2, SLC39A2, 6A1, Eti-1, ZIP2)

Pricing

  For pricing information, USA customers sign in.
  Outside USA? Please contact your distributor for pricing.

Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
Zinc is an essential nutrient for all organisms because of the many important roles this metal plays. Movement of zinc into and out of cells and subcellular organelles is mediated by zinc transporter proteins. In many organisms, zinc uptake is mediated by members of the ZIP family of metal ion transporters. In mammals, the Zip1, Zip2, Zip3, Zip4, Zip5, LIV- 1 (Zip6), KE4 (Zip7), and BIGM103 (Zip8) proteins have been implicated in zinc uptake in a variety of cell and tissue types.
Catalog #Z0510-03
ZIP2 ((SLC39A2; Eti-1; 6A1)) encodes a protein of 309aa, includes an amino terminal signal peptide of 26aa, and has the predicted topology of Zip proteins. The human or mouse Zip2 overexpression in transfected K562 and human embryonic kidney (HEK293) cells, respectively, increased 65Zn uptake in these cells. hZIP2-induced Zn uptake was shown to be highly inhibited by Mn2+ and Co2+, metals that did not substantially affect hZIP1-, mZIP1-, or mZIP2-induced Zn uptake. Zn uptake mediated by hZIP2 appears to be stimulated by HCO 3, non-ATP dependent, but sensitive to N-ethylmaleimide, a sulfhydryl-reactive agent.
ApplicationsSuitable for use in Western Blot, ELISA. Other applications not tested.
Recommended DilutionWestern Blot: 1-10ug/ml (Chemiluminescence)
ELISA: 1:100,000
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O or PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a lyophilized powder from PBS, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to 19aa of human ZIP2 (Accession #AAI13770), N-terminal, Extracellular domain (KLH).
SpecificityRecognizes human ZIP2. Species sequence homology: mouse (84%).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


External Links