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You are here:Home » Antibodies » Antibodies-Connexin, Junction Proteins » Anti -ZO-2 (Tight Junction-associated Polypeptide, Zonula Occludens 2)

Anti -ZO-2 (Tight Junction-associated Polypeptide, Zonula Occludens 2)


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Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IP IF
The zonula occludens proteins (ZOPs), ZO-1, ZO-2 and ZO-3 are tight-junction phosphorylated proteins that belong to the membrane-associated guanylated kinase (MAGUK) family. ZOs are involved in the organization of epithelial and endothelial intercellular junctions and bind to the cytoplasmic C-termini of junctional transmembrane proteins linking them to the actin
cytoskeleton, ZOPs contain three PDZ domains, one SH3 domain, and a guanylate kinase-like domain, indicating that ZOPs may serve multiple purposes. ZOPs contain some unique motifs not shared by other MAGUK family members, including nuclear localization and nuclear export signals and a leucine zipper-like sequence. Their potential involvement in cell growing and proliferation has been suggested based on the observation that the N-terminal half of ZOPs displays a significant similarity to the product of the Drosophila tumor suppressor gene lethal disc-large (dlg).
Catalog #Z0760-01
ApplicationsSuitable for use in Immunoprecipitation, Western Blot, Immunofluorescence and ELISA. Other applications have not been tested.
Recommended DilutionImmunoprecipitation (Native): 5-10ug
Western Blot: 1-3ug/ml
Immunofluorescence: 1-3ug/ml
ELISA (Native): 0.1-1ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlsHuman CaCo2 and Canine MDCK cell lysates
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
Clone No6A219
FormSupplied as a liquid in PBS, pH 7.4, 0.1% sodium azide
PurityPurified by Protein A affinity chromatography.
ImmunogenSynthetic peptide corresponding to internal amino acids of the human ZO-2 protein.
SpecificityRecognizes human ZO-2 at ~160kD. Species Crossreactivity: canine.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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