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Axol > AD hNPCs

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Axol Alzheimer's Disease Neural Progenitor Cells
(AD hNPCs)

 

Model Alzheimer's Disease in a Dish

Alzheimer’s disease is an incurable, fatal neurodegenerative disorder now affecting over 24 million people worldwide and that is predicted to reach 100 million by 2050. Without an effective treatment, our aging society will soon face an Alzheimer’s disease epidemic that will ultimately lead to social catastrophe and saddle heavy economic burden on our healthcare systems.

Alzheimer's research will provide insights which will help to prevent and cure the disease. Up to now, the research has heavily relied upon genetically modified animal models which are time consuming and expensive to produce, maintain and experiment on. Our human iPS cell-derived AD hNPCs provide scientists an affordable and easily accessible platform for building their own human cellular models of Alzheimer's disease in a disease-relevant genetic and tissue context.

 

 

Cat #

Product Name

Genotype

Donor Age

Clinically diagnosed w/ AD

Starting Material

Reprogramming Method

Neural Induction Method

Size

ax0111 AD hNPC
APOE4
APOE4 Homozygotes 87 YR Yes Dermal Fibroblasts Episomal Plasmid Monolayer
Chem-defined medium
2M
cells
ax0112 AD hNPC
Presenilin-1 Mutation L286V
Presenilin-1 Mutation L286V 38 YR Yes Dermal Fibroblasts Episomal Plasmid Monolayer
Chem-defined medium
2M
cells
ax0113 AD hNPC
Presenilin-1 Mutation M146L
Presenilin-1 Mutation M146L 53 YR Yes Dermal Fibroblasts Episomal Plasmid Monolayer
Chem-defined medium
2M
cells
ax0114 AD hNPC
Presenilin-1 Mutation A246E
Presenilin-1 Mutation A246E 31 YR Yes Dermal Fibroblasts Episomal Plasmid Monolayer
Chem-defined medium
2M
cells
ax0115 AD hNPC
Presenilin-1 Mutation N141l
Presenilin-1 Mutation N141l 81 YR Yes Dermal Fibroblasts Episomal Plasmid Monolayer
Chem-defined medium
2M
cells

 


Advantages of Axol hNPCs

Specifications

Applications

  • Human cells derived from diagnosed Alzheimer's disease patients
  • Available in industrial quantity
  • High purity neural progenitor population
  • Ready-made and easy to differentiate
  • Robust enough to undergo genetic manipulation
  • Supplied with extensive functional and molecular characterization data
  • Capable of differentiating to a spectrum of cortical excitatory and inhibitory neurons
  • Remain viable in culture for months to facilitate reproducible and long term studies
  • Cells from multiple donors are available for purchase allowing data comparison among biological replicates
  • Quantity: 2 million expandable cells per vial
  • Presentation: Cells are provided cryopreserved in 1 ml of
  • zing medium
  • Storage Condition: Liquid nitrogen
  • Growth Properties: Adherent 
  • Studying AD pathogenesis at cellular level
  • Studying neural network formation and signal transmission in AD neural culture
  • Neurotoxicity testing
  • Preclinical drug efficacy testing

 

 

One vial of Axol AD hNPCs (2 million cells) can give rise to two 6-well plates of mature functional neurons at 70% confluence (12 million cells).