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Axol Human Cerebral Cortical Neurons
(hCCNs Plated)

Axol Cerebral Cortical neurons, microtiter plate, and protocolAxol hCCNs are derived from integration-free, induced pluripotent stem (iPS) cells under fully defined neural induction conditions..

These cells express typical markers of cerebral cortical neurons, such as Tbr1, Ctip2, Brn2 and Cux1 (see below). They are electrically active and able to form functional synapses and circuits in culture. 

Cerebral cortical neurons are implicated in numerous neurological diseases including Alzheimer’s disease, autism, epilepsy and stroke. Despite strong interest in these diseases, high quality human in vitro cell models for cortical neurophysiology have been unavailable until now. With Axol hCCNs, we provide neuroscience researchers with a high quality in vitro human system to complement their existing studies of cortical development, function and diseases using animal models.

 

Axol Cerebral Cortical Neurons fluorescent images

 

Cat #

Product Name

Gender

Donor Age

Starting Material

Reprogramming Method

Neural Induction Method

Genetic Mod.

Size

ax0021 hCCN
Donor A
Male New Born Cord Blood CD34+ Cells Episomal Plasmid Monolayer
Chem-defined medium
No 6M cells in 96-well format
ax0023 hCCN
Donor C
Male New Born Cord Blood CD34+ Cells Episomal Plasmid Monolayer
Chem-defined medium
No 6M cells in 96-well format
ax0024 hCCN
Donor D
Female New Born Cord Blood CD34+ Cells Episomal Plasmid Monolayer
Chem-defined medium
No 6M cells in 96-well format
ax0025 hCCN
Donor E
Male New Born Cord Blood CD34+ Cells Episomal Plasmid Monolayer
Chem-defined medium
No 6M cells in 96-well format
ax0026 hCCN
Donor F
Female New Born Cord Blood CD34+ Cells Episomal Plasmid Monolayer
Chem-defined medium
No 6M cells in 96-well format

 


Advantages of Axol hCCNs

Specifications

Applications

  • Human cells
  • Available in industrial quantity
  • Ready-made and fully functional
  • Supplied with extensive functional and molecular characterization data
  • Include a spectrum of cortical neurons
  • Remain viable in culture for months to facilitate reproducible and long term studies
  • Cells from multiple donors are available for purchase allowing data comparison among biological replicates
  • Quantity: 6 million functional cells per plate
  • Presentation: Pre-plated in 96-well format & delivered fresh!
  • Storage Condition: Tissue culture incubator (setting: 37 degree celsius & 5% CO2)
  • Growth Properties: Adherent 
  • Studying Corticogenesis in vitro
  • Studying neural network formation and signal transmission  
  • Disease modelling
  • Neurotoxicity testing
  • Preclinical drug efficacy testing