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c-Jun

Confocal immunofluorescent image of C6 cells, anisomycin treated, and stained with c-Jun antibody [C5815-11] (green) and beta-Tubulin antibody (red) with blue fluorescent DNA dye.
Figure 1. Confocal immunofluorescent image of C6 cells, anisomycin treated, and stained with c-Jun antibody [C5815-11] (green) and beta-Tubulin antibody (red) with blue fluorescent DNA dye.

c-Jun is a major component of the heterodimeric transcription factor AP-1 and is essential for embryonic development. It mediates several cellular processes, including proliferation and survival, and is up-regulated in many carcinomas. Transactivation of c-Jun is regulated by Jun-N-terminal Kinases (JNKs) through phosphorylation at Serine 63 and 73, as well as at threonine 91 and 93.

Evidence supports that phosphorylation in NH2-terminal residues of c-Jun stimulates the dephosphorylation of the COOH-terminal sites, and consequently increases the DNA-binding activity of the transcription factor. c-Jun N-terminal kinase (JNK) isoforms are required for the phosphorylation of Threonine 91 and 93 in response to anisomycin in macrophages and TNF-alpha or anisomycin in fibroblasts.

 

 

 

 

 

Selected c-Jun products

 

Catalog #

Product Name

Type

Host

Source

C5815-08 c-Jun Control Cell Extracts      
C5815-10A c-Jun, phosphorylated (Ser63) Control Peptide      
C5815-10C c-Jun, phosphorylated (Ser63) ELISA, BioAssay™, Antibody Pair      
C5815-10D c-Jun Sandwich ELISA, BioAssay™, Antibody Pair      
C5815-10G c-Jun, Total, ELISA Kit (Antibodies Only)      
C5815-10H c-Jun, Total, Sandwich ELISA Kit (Qualitative)      
C5815-12D c-Jun, phosphorylated (Ser73) Control Peptide      
C5815-15 c-Jun (Ser63) II, c-Jun (Ser73) BioAssay™ Phosphorylation Detection Kit      
C5815 c-Jun Pab Rb x Ch
C5815-01A c-Jun Pab Rb x Hu
C5815-01B c-Jun Pab Rb x Hu
C5815-01C c-Jun Pab Rb x Hu
C5815-01D c-Jun Pab Rb x Hu
C5815-01E c-Jun Pab Rb x Hu
C5815-01F c-Jun Pab Rb x Hu
C5815-03A c-Jun, CT Mab Rb x Hu
C5815-03B c-Jun, NT Mab Rb x Hu
C5815-03C c-Jun, phosphorylated, Ser63 Mab Rb x Hu
C5815-05B c-Jun Pab Rb x Hu
C5815-10 c-Jun, phosphorylated (Ser63) Pab Rb x Hu
C5815-10L c-Jun Pab Rb x Hu
C5815-11 c-Jun, phosphorylated (Ser73) Pab Rb x Hu
C5815-11H c-Jun, phosphorylated (Ser243) Pab Rb x Hu
C5815-12E c-Jun, phosphorylated (Thr91) Pab Sh x Hu
C5815-12F c-Jun, phosphorylated (Thr91) Pab Rb x Hu
C5815-14 c-Jun, phosphorylated (Thr91, Thr93) Pab Rb x Hu
C5815-14A c-Jun, phosphorylated (Thr93) Pab Rb x Hu
C5815-14M c-Jun, phosphorylated (Thr 239) Pab Rb x Hu
C5815-16 c-Jun, phosphorylated (Tyr170) Pab Rb x Hu