CD47: Promising target for solid tumor treatment

IHC staining of Formalin-Fixed, Paraffin-Embedded (FFPE) Placenta, Human: using C2402-02D.

In a recent article in the Proceedings of the National Academy of Sciences, Willingham et al., have found that CD47 is expressed on a wide range of human solid tumors, perhaps as the one constant change in all human aggressive neoplasms. The authors have also validated one function of CD47 on these cancers, as a “don’t eat me” signal. CD47 therefore serves as an attractive target for cancer therapies. They further demonstrated that monoclonal antibodies that block CD47 are effective for treating human solid tumors in vitro and in vivo.

Willingham, S.B. et al., “The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors “ (2012) PNAS, doi: 10.1073/pnas.1121623109

Selected CD47 Products