Login

Forgot your password?
New User?
Remember me
banner banner

 CD47: Promising target for solid tumor treatment

IHC staining of Formalin-Fixed, Paraffin-Embedded (FFPE)  Placenta, Human: using C2402-02D
IHC staining of Formalin-Fixed, Paraffin-Embedded (FFPE) Placenta, Human: using C2402-02D.

In a recent article in the Proceedings of the National Academy of Sciences, Willingham et al., have found that CD47 is expressed on a wide range of human solid tumors, perhaps as the one constant change in all human aggressive neoplasms. The authors have also validated one function of CD47 on these cancers, as a “don’t eat me” signal. CD47 therefore serves as an attractive target for cancer therapies. They further demonstrated that monoclonal antibodies that block CD47 are effective for treating human solid tumors in vitro and in vivo.

Willingham, S.B. et al., “The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors “ (2012) PNAS, doi: 10.1073/pnas.1121623109

 

Selected CD47 Products

Catalog #

Product Name

Type

Host

Source

C2402-02 CD47 Mab Mo x Hu
C2402-02C CD47 (Leukocyte Surface Antigen CD47, Antigenic Surface Determinant Protein OA3, Integrin-associated Protein, IAP, Protein MER6, MER6) (Azide Free) Mab Mo x Hu
C2402-03F CD47 Mab Mo x Hu
C2402-03G2 CD47 (CD47 Antigen, Antigenic Surface Determinant Protein OA3, Integrin Associated Protein, IAP, Integrin Associated Signal Transducer, Leukocyte Surface Antigen CD47, MER6, OA3, Protein MER6, Rh-related Antigen) Mab Mo x Hu
C2402-03R CD47 (Leukocyte Surface Antigen CD47, Antigenic Surface Determinant Protein OA3, Integrin-associated Protein, IAP, Protein MER6, MER6) Mab Mo x Hu
C2402-04 CD47 Mab Mo x Rt