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CLOCK

Monarch Butterlfy

CLOCK, a basic helix-loop-helix (bHLH)/PAS protein, is an important factor in the molecular clock mechanism. Mutations in this protein lead to abnormal circadian behavior and defective transcriptional activity. CLOCK has been shown to interact strongly with other bHLH-PAS proteins such as MOP3, a BMAL1 isoform.

Circadian rhythm is one of the most fascinating and complex biological phenomena. The circadian clock controls biological activities on daily light-dark cycles in species from cyanobacteria to humans. The circadian clock has three major components: A photoactive pigment (chromophore) for sensing light and transmitting light signals, the circadian clock that oscillates every ~24-hrs, and the genes controlled by the circadian clock to bring about the physiological and behavioral changes.

Surprisingly, Monarch butterflies have not only the drosophila-like version of the body clock protein CRY, but also another that further tests identified as a new clock molecule in the butterfly. This new clock protein, dubbed CRY2, is more similar to the protein found in humans.

 

Select United States Biological CLOCK Products

 

Catalog #

Product Name

C5843-01A CLOCK
C5843-02A Clock
C5843-02B CLOCK, ID
C5843-02C CLOCK
C5843-04 Clock, CT
C5843-05 Clock, NT
C5843-14 Clock
C5843-16 Clock
P3342-01E Period Clock Protein 1
P3342-01F Period Clock Protein 1
P3342-01G Period Clock Protein 1
P3342-01H Period Clock Protein 1
P3342-02 Period Clock Protein 1
P3342-02A Period Clock Protein 1
P3342-02B Period Clock Protein 1
P3342-20D Period Clock Protein 2
P3342-20E Period Clock Protein 2
P3342-20F Period Clock Protein 2
P3342-26 Period Clock Protein 2