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Fibrinogen

Protein Concentration graph for Fibrinogen

Fibrinogen is the main protein of blood coagulation system. It is a large protein and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A (1-16 amino acids) and B (1-17 amino acids) are released by thrombin from the N-terminal parts of alpha- and beta-chains, respectively. In this way fibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen activation is also involved in pathogenesis of inflammation, tumor growth and many other diseases.  

The normal fibrinogen concentration in plasma is about 3 mg/ml. The elevated level of fibrinogen in patient's blood is regarded as an independent risk factor for cardiovascular diseases. An increase in blood fibrinogen concentration was shown to be a strong predictor of coronary heart disease (Sonel A. et al, and Rapold H.J. et al). All these facts make fibrinogen an important parameter in the diagnosis of cardiovascular diseases.

 

Catalog #

Product Name

Type

Host

Source

Apps

F4199-90 Fibrinogen (Coagulation Factor I) Pab sheep Hu D
F4199-91 Fibrinogen (Coagulation Factor I) Mab mouse Hu E RIA WB
F4199-91A Fibrinogen (Coagulation Factor I) Pab sheep Hu IHC
F4200-04 Fibrinogen (Coagulation Factor I) Pab chicken Hu E WB
F4199-92 Fibrinogen (Coagulation Factor I) Mab mouse   E WB
F4199-92A Fibrinogen (Coagulation Factor I) Mab mouse   E WB
F4199-92D Fibrinogen (Coagulation Factor I) Mab mouse   E WB
F4199-92E Fibrinogen (Coagulation Factor I) Mab mouse   E WB
F4200-07 Fibrinogen (Human Plasma) Pab goat Hu E IP WB
F4200-07A Fibrinogen (Human Plasma) Pab goat Hu E IP WB
F4199-91B Fibrinogen (Coagulation Factor I) Mab mouse Hu E WB
F4199-91C Fibrinogen (Coagulation Factor I) Mab mouse Hu E WB
F4203-06 Fibrinogen (Coagulation Factor I) Mab mouse Hu E WB
F4203-06A Fibrinogen (Coagulation Factor I) Mab mouse Hu E WB
F4203-06B Fibrinogen (Coagulation Factor I) Mab mouse Hu E WB
F4203-06C Fibrinogen (Coagulation Factor I) Mab mouse Hu E WB
F4203-06D Fibrinogen (Coagulation Factor I) Mab mouse Hu E WB
F4203-06K Fibrinogen (Coagulation Factor I) Mab mouse Hu E WB
F4203-06L Fibrinogen (Coagulation Factor I) Mab mouse Hu E WB
F4203-06M Fibrinogen (Coagulation Factor I) Pab goat Hu E IP WB
F4204-06 Fibrinogen-like Protein 2 (FGL2, Fibrinogen-like 2, Fibroleukin, pT49, T49) (Azide Free) Mab mouse Hu E IHC WB
F4203-02F Fibrinogen (Fibrinogen A alpha Polypeptide, Fibrinogen alpha Chain, FGA, Fibrinogen B alpha Polypeptide, Fibrinogen beta Chain, FGB, Fibrinogen G alpha Polypeptide, Fibrinogen gamma Chain, FGG, 2510049G14Rik, 3010002H13Rik, Ab1-181, Ab1-216, Ac1-581, Ac1873, AI256424, ENSMUSG00000059807, Fba5e, Fib, Fib2, MGC104327, MGC119422, MGC119423, MGC119425, MGC120405, MGC156536, PRO2061) Pab sheep Hu E IF IHC
F4203-08B Fibrinogen, oxidized, soluble Pab rabbit Hu E
F4203-08C Fibrinogen, Oxidized (insoluble fraction) Pab rabbit Hu E
F4197-37 Fibrin, Fibrinogen Mab mouse   E xIHC
F4203-06Q FGA, NT (Fibrinogen alpha Chain, Fibrinopeptide A) Pab rabbit Hu E WB
F4203-03A Fibrinogen, Citrullinated (FGA, FGB, FGG, Fibrinogen A alpha Polypeptide Chain, Fibrinogen alpha Chain, Fibrinogen beta Chain, Fibrinogen gamma Chain, MGC104327, MGC119422, MGC119423, MGC119425, MGC120405) Mab mouse Mo E
F4203-03C Fibrinogen, Citrullinated (FGA, FGB, FGG, Fibrinogen A alpha Polypeptide Chain, Fibrinogen alpha Chain, Fibrinogen beta Chain, Fibrinogen gamma Chain, MGC104327, MGC119422, MGC119423, MGC119425, MGC120405) Mab mouse Mo E
F4204-05 Fibrinogen-like Protein 1 (FGL1, Hepassocin, Fibrinogen-like 1) Pab goat Hu E WB