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MetaboLyte™ Production Platform

From Screening To Optimization To Production

United States Biological and HepatoChem™ have teamed up to offer a revolutionary way to screen, optimize, and produce metabolites from drug candidates.

HepatoChem™ technology exploits an optimized panel of catalytic chemical reaction conditions in a multi-well parallel format which, by its diversity, mimics the suite of cytochrome P450 enzymes (CYP) present in human hepatocytes, offering the researcher a unique, synthetic chemical liver.


Exciting new technology speeds up metabolite study.

  • Produce drug metabolites in days, not months.
  • Exclusive process produces large quantities of metabolites.
  • Rapid, inexpensive scale up for NMR and in vitro testing.
  • Eliminate complex and costly synthetic chemistries.

 

HepatoChem™ Technology

Our innovative approach is based on a diverse set of chemical conditions that mimics the main reactions occurring during drug metabolism. This panel is used to quickly find reaction conditions that generate specific drug metabolites. This HepatoChem™ approach, basically a chemical liver, is analogous to the panel of cytochromes P450 present in the human liver, but with the advantage of the scalability of chemistry. When a reaction condition is identified, it is optimized and scaled up to produce mg to g quantities of metabolites.

HepatoChem™ developed a series of biomimetic panels. These panels are using several kinds of catalysts, including metalloporphyrins, which gives access to a unique set of reaction conditions. This series of easy-to-use kits is suitable for the preparation of metabolites for MSMS and NMR.

 

Key Benefits

Direct synthesis of Metabolites from parent drug
Authentication with biological reference samples
Rapid optimization in hours
Milligram to gram scale
Common Biotransformation Reactions

  • Aliphatic Hydroxylation
  • N-Dealkylation
  • O-Dealkyation
  • Cleavage
  • N-Oxidation
  • S-Oxidation
  • Rearrangement
  • Formylation

 

MetaboLyte™ Biomimetic Oxidation Kits

Three kits are being introduced to help the researcher produce metabolites for their drug candidates. These kits perform a one-step synthesis of metabolites from the parent drug.

  • Fast
  • Inexpensive
  • Reproducible
  • Scaleable from ug to mg to gram
  • Convenient Room Temperature reagents
  • Easy to use

 

Screening Kit
M3008-10

Optimization Kit
M3008-20

Production Kit
M3008-30

Complete Kit includes all solvents and reagents for 2x22 screening reaction conditions. 2 plates included. Complete Kit includes all solvents and reagents for optimization of selected screening reaction conditions. 1 plate included. Complete Kit includes all solvents and reagents needed to produce your metabolite at 0.01 mmol scale.
1
Perform the primary screen. Select desired metabolite wells. Order corresponding optimization kit.
2
Perform the optimization kit. Identify best production conditions Order corresponding production kit.
3
Scale-up and isolate your metabolite.

 

The HepatoChem™ Edge From Research to Market, Saving Time And Money

 

Access to metabolites is critical at every stage of the drug discovery process. Research Stage
Structure elucidation of drug metabolites allows faster metabolic stability optimization and also provides an opportunity to identify unique analogues.
metabolite pipeline hepatochem united states biologicalMetaboLyte™ provides you suitable quantities of metabolites from pre-IND to Clinical stage. Pre-clinical Stage
Biological profiling and toxicology studies of lead compound metabolites are critical to improve the quality of the pipeline and reduce attrition rates. Significantly, the FDA published a guidance on safety studies of metabolites in 2008. Guidance for industry, Safety testing of drug metabolites, FDA, February 2008.
Clinical Stage
Quantification studies necessitate access to pure samples of metabolites. Metabolite IP permits full protection of related, marketed drugs.