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Psoriasis: symptoms and recent research


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C3980-01C Chitinase 3-like 3
G1040-01 Galactose Oxidase, Liquid
P4079-01D (6-4) Photoproducts
T5151-09 Thymine Dimer




SMAD1 is also known as Mothers Against Decapentaplegic homolog 1, Mothers against DPP homolog 1, hSMAD-3, JV4-1, Transforming growth factor-Beta-Signaling Protein 1 or BSP1. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. SMAD1, as a transcriptional modulator, is activated by BMP (Bone Morphogenetic Protein) type 1 receptor kinase (it is a receptor-regulated SMAD or R-SMAD). BMPs are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses.


Cartoon of SMAD1 structure created using Cn3D

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S1014-50C Smad1
S1014-50E SMAD1, phosphorylated (Ser465)
S1014-50F SMAD1, phosphorylated (Ser206)
S1014-51 Smad1, phosphorylated (Ser463,465)


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FEATURED MagSi particles coated with lectins for glycoproteomics studies

Schematic of magnetic silica bead with a variety of functional conjugates.Schematic of magnetic silica bead with a variety of functional conjugates.
Schematic of magnetic silica bead with a variety of functional conjugates.

Alterations in protein glycosylation occur during development, and in the progression of many diseases including cancer, inflammation and autoimmune diseases. The recent field of glycoproteomics has emerged as an important tool in glycobiomarker discovery. The most frequently studied lectin for capture of glycosylated proteins is Concanavalin A (Con A). In addition, there exist ~20 more lectins with different individual selectivity towards glycosylated structures. Because of the variety of carbohydrates that are recognized by the lectin family, a comprehensive glycoproteomics study should include the ability to analyze multiple lectins.


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ARTICLE Psoriasis: symptoms and recent research

photo of a plaque of psoriasis
Photo of plaque psoriasis on an arm.
There have been several interesting advances in the study of psoriasis recently, including the analysis of a genetic component (1,2), the effectiveness of psoriasin as a target for therapy (4), an examination of the T-cell–driven immune response observed during flare-ups (6), and the report of positive results in a Phase II clinical trial for treatment of plaque psoriasis symptoms (7-9). This review includes a background on the symptoms and manifestations of psoriasis, along with a brief description of current advances in this field.


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C5820-01A CLAN Pab Rb x  
I0610-12 Ice Protease Activating Factor Pab Rb x  
S0051-85H S100A7 Mab Mo x Hu
I8439-04L Interleukin 17 Mab Rt x Mo


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