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Drug Identified as Candidate for Amoebic Dysentery Treatment

 
 

NEW Products

 
 

Catalog #

Product Name

A1373-01 D-Amino Acid Oxidase, Porcine Kidney
C7850-70D Complement Factor D
C7850-70E Complement Factor D (Biotin)
D9517-03A Drop-out Mix Synthetic Minus Leucine, Tyrosine, Uracil w/o Yeast Nitrogen Base (Powder)
D9517-03B Drop-out Mix Synthetic Minus Uracil, Histidine, Arginine w/o Yeast Nitrogen Base (Powder)
E2213-77 rac Efavirenz-d5 (major)
I7662-10N Interferon, beta, neutralizing (Interferon beta, IFN-beta, Fibroblast Interferon, IFB, IFNB)
M9557-01 MutS
M9557-01A MutS, Magnetic Mismatch Binding Beads (M2B2), MagDetect™

 
 

SPECIAL c-Jun

 
 

c-Jun is a major component of the heterodimeric transcription factor AP-1 and is essential for embryonic development. It mediates several cellular processes, including proliferation and survival, and is up-regulated in many carcinomas. Transactivation of c-Jun is regulated by Jun-N-terminal Kinases (JNKs) through phosphorylation at Serine 63 and 73, as well as at threonine 91 and 93.

 

c-jun

Catalog #

Product Name

C5815-08 c-Jun Control Cell Extracts
C5815 c-Jun
C5815-10 c-Jun, phosphorylated (Ser63)
C5815-14 c-Jun, phosphorylated (Thr91, Thr93)

 

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FEATURED Cell Lysate

 
 
crp depleted serum

Cell lysates are useful in Western Blot applications as a positive control for many antibodies. Most cell lysates are prepared by homogenization in modified RIPA buffer (150mM sodium chloride, 50mM Tris-HCl, pH 7.4, 1mM ethylenediaminetetraacetic acid, 1mM phenylmethylsulfonyl flouride, 1% Triton X-100, 1% sodium deoxycholic acid, 0.1% sodium dodecylsulfate, 5ug/ml of aprotinin, 5ug/ml of leupeptin).

 

 

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ARTICLE Amoebic Dysentery Treatment

 
 
amoebic dysentery
Trophozoites of Entamoeba histolytica with ingested erythrocytes (trichrome stain). The ingested erythrocytes appear as dark inclusions.

An inexpensive arthritis drug called auranofin has been shown in lab and animal tests to kill the parasites that cause amoebic dysentery and giardiasis1, 2. The gold-containing drug, marketed under the trade name Ridaura, has already been demonstrated to be safe in humans, is much more powerful than existing treatments. Human trials are expected to start soon for this new application.

 

 

Catalog #

Product Name

Type

Host

Source

E3250-10 Entamoeba histolytica Mab Mo x  
G2034-17 Giardia lamblia Pab Gt x  
T5010-14B Thioredoxin Reductase Pab GT x Hu
T5010-17A Thioredoxin Reductase BioAssay™ Kit (TrxR)      

 

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