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Having trouble reading this? Click here for web version.United States Biological
July 2009 Issue 1| Subscribe                                                                                               www.usbio.net

Protein Kinases:
kinaseProtein kinases modify other proteins by adding phosphate groups to them. A simple chemical step, but with profound implications. For your kinase-related research, United States Biological carries a full range of protein kinases, including Serine/threonine-specific protein kinases and Tyrosine-specific protein kinases.

mung bean  sproutsTyrosine Kinase

A sampling of MAP Kinases and Phosphatases :

Akt1, active, Recombinant, Human (Rac PKa, PKBa)
Human Akt1 (GenBank Accession No. NM_001014432), full length (a.a. 1-480) with N-terminal GST tag, co-expressed with PDK1 in an Baculovirus infected Sf9 cell expression system.

CDK5/p25, active, Recombinant, Human (Cyclin-Dependent Kinase 5)
Recombinant full-length human CDK5 and human p25 were co-expressed in Sf9 cells using an N-terminal GST tags. The CDK5 gene accession number is NM_004935 and p25 gene accession number is NM_003885.

MEG1 (Protein Tyrosine Phosphatase, Non-receptor Type 4)
Protein Tyrosine Phosphatase catalytic domain, (a.a. 637-926), MW=60.3kD, expressed in an E.coli expression system.

DEP1, Protein Tyrosine Phosphatase, Recombinant, Human (Density-enhanced Phosphatase-1, PTP-eta, CD148)
Catalytic domain, (a.a. 1024-1306), MW=32.9kD, expressed in an E. coli expression system.

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Protein Phosphatases:
phosphataseProtein phosphatases remove phosphate groups from from their substrates and are integral to many signal transduction pathways. USBiological offers a wide selection of these proteins as well, including Serine/threonine-specific protein phosphatases and Tyrosine-specific protein phosphatases.

This month's Special:
10% off MAP3K14 (NIK) and Protein Tyrosine Phosphatase 1B

P9109-01A Protein Tyrosine Phosphatase 1B , N2567-05 MAP3K14 (NIK)

MAP3K14 (NIK; mitogen-activated protein kinase kinase kinase 14) is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity.

Protein tyrosine phosphatase (PTP) 1B is believed to function as a negative regulator of multiple signaling pathways downstream of receptor tyrosine kinases.


Protein Tyrosine Phosphatase

Serine/Threonine Protein Kinases
the MAPK Pathway

MAP (mitogen-activated protein) kinases are serine/threonine-specific protein kinases that respond to a large variety of extracellular stimuli and regulate various cellular activities, such as growth, mitosis, differentiation, inflammation and apoptosis.

In general, the pathway begins with a stimulus, then goes through the following cascade: MAP Kinase Kinase Kinase>phosphorylates MAP Kinase Kinase on its serine and threonine residues> phosphorylates MAP Kinase on its serine and tyrosine residues> resulting in the response.




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