April Deal: 10% Off GMO Kits

   Our Biogenomics™ GMO Real-time PCR Kits and Detection Kits are designed for the screening and detection of Genetically Modified Organisms in seed, crop, raw materials, and processed food. After DNA extraction using one of our Extraction Kits simply mix the extracted DNA with the Kit's reagents, do a PCR or Real-time PCR run, and analyze.The whole process takes only 4.5 hours.

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Featured Product: Histones

Modulation of the chromatin structure plays an important role in the regulation of transcription in eukaryotes. The nucleosome, made up of four core histone proteins (H2A, H2B, H3 and H4), is the primary building block of chromatin. The N-terminal tail of core histones undergoes different post-translational modifications including acetylation, phosphorylation and methylation. These modifications occur in response to cell signal stimuli and have a direct effect on gene expression.

Featured Article: HERV's

The human genome contains about 8% of sequences of retroviral origin, remnants of different exogenous retrovirus infections of the germ line genome that occurred millions of years ago. Endogenous retroviruses may be a variant of a retrovirus that became permanently integrated with its host and is inherited from generation to generation as part of the genome of the host.

Retroviruses are single-stranded RNA viruses that reverse-transcribe their RNA into DNA for integration into the host's genome. Most retroviruses (such as HIV-1) infect somatic cells, but in very rare cases, it is thought that exogenous retroviruses have infected germline cells (cells that make eggs and sperm) allowing integrated retroviral genetic sequences to be passed on to subsequent offspring, thereby becoming 'endogenous'. Endogenous retroviruses have persisted in the genome of their hosts for thousands of years. However, they are generally only infectious for a short time after integration as they acquire many inactivating mutations during host DNA replication. They can also be partially excised from the genome by a process known as recombinational deletion. They are thought to play a key role in evolution.

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