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New Products: Rabbit Plasma, Sera, and Tissues United States Biological supplies rabbit serum, plasma, and tissue products for use in diagnostics and molecular biology research. All raw materials are collected from licensed USDA facilities and are certified to be free of infectious diseases. Manufacturing batch records are kept on file, maintaining complete traceability to raw material and production processes.
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July Special: 10% Off Select Human Recombinant Proteins There are two main systems available for the expression of recombinant proteins; prokaryotic (bacterial) and eukaryotic (yeast or mammalian). Prokaryotic expression systems have several advantages including, cost, culture conditions, rapid cell growth, yield and relatively short expression time. However, if the protein is required for functional or enzymatic studies, prokaryotic systems may not be the most suitable, as many proteins will form insoluble aggregates known as inclusion bodies which after refolding may not retain their biological function. Furthermore, bacterial expression systems do not allow for any post-translational modifications to be made (e.g. phosphorylation) which may be necessary for biological activity.
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Fibrinogen is the main protein of blood
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coagulation system. It is a large protein and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A (1-16 amino acids) and B (1-17 amino acids) are released by thrombin from the N-terminal parts of alpha- and beta-chains, respectively. In this way fibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen activation is also involved in pathogenesis of inflammation, tumor growth and many other diseases.
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Featured Article: Zebrafish What does it take to regenerate a limb? When a zebrafish loses its fin, a special group of cells forms on the remaining stump. These cells, which appear identical to one another, regrow the entire limb, complete with all cell types required for a complex organ. This has suggested that these cells may be “pluripotent” stem cells, capable of forming almost every tissue in the body.
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scientific research. Small, semi-transparent freshwater fish, they reproduce rapidly and their transparent embryos develop outside the body. Such traits are helpful for viewing biological processes within the embryo or adult tissues.