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SMAD1

Cartoon of SMAD1 structure created using Cn3D
Figure 1. Cartoon of SMAD1 structure created using Cn3D.

SMAD1 is also known as Mothers Against Decapentaplegic homolog 1, Mothers against DPP homolog 1, hSMAD-3, JV4-1, Transforming growth factor-Beta-Signaling Protein 1 or BSP1. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. SMAD1, as a transcriptional modulator, is activated by BMP (Bone Morphogenetic Protein) type 1 receptor kinase (it is a receptor-regulated SMAD or R-SMAD). BMPs are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. SMAD proteins have been implicated as downstream effectors of TGF beta/BMP signaling. In response to BMP ligands, SMAD1 can be phosphorylated (other sites besides the most prominent of S206, are S187, S195, and S214). S-206 is phosphorylated by ERK in response to mitogenic growth factors, or by recombinant ERK in vitro; this can be tested by treating cells with EGF or in cancer cells where Ras is activated. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is also a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation

 

 

Selected Psoriasis Related Antigens and Antibodies

 

Catalog #

Product Name

Type

Host

Source

S1014-50C Smad1 (MADR1, Small Mothers Against Decapentaplegic Deleted in Pancreatic Carcinoma) Pab Rb x Hu
S1014-50D Smad1 (MADR1, Small Mothers Against Decapentaplegic Deleted in Pancreatic Carcinoma) Mab Mo x Hu
S1014-50E SMAD1, phosphorylated (Ser465) (Mothers Against Decapentaplegic Homolog 1, Mothers Against DPP Homolog 1, MAD Homolog 1, MADH1, SMAD Family Member 1, SMAD 1, hSMAD1, BSP-1, BSP1, JV4-1, JV41, Mad-related Protein 1, MADR1, Transforming Growth Factor-beta-signaling Protein 1) Pab Rb x Hu
S1014-50F SMAD1, phosphorylated (Ser206) (Mothers Against Decapentaplegic Homolog 1, Mothers Against DPP Homolog 1, MAD Homolog 1, MADH1, SMAD Family Member 1, SMAD 1, hSMAD1, BSP-1, BSP1, JV4-1, JV41, Mad-related Protein 1, MADR1, Transforming Growth Factor-beta-signaling Protein 1) Mab Rb x Hu
S1014-51 Smad1, phosphorylated (Ser463,465) (Small Mothers Against Decapentaplegic Deleted in Pancreatic Carcinoma) Pab Rb x Hu
S1014-51A Smad1, phosphorylated (Ser206) (Small Mothers Against Decapentaplegic Deleted in Pancreatic Carcinoma) Pab Rb x Hu
S1014-51B SMAD1, phosphorylated (Ser465) (Mothers Against Decapentaplegic Homolog 1, MAD Homolog 1, Mothers Against DPP Homolog 1, JV4-1, Mad-related Protein 1, SMAD Family Member 1, SMAD 1, hSMAD1, Transforming Growth Factor-beta-signaling Protein 1, BSP-1, BSP1, MADH1, MADR1) Pab Rb x Hu
S1014-51C SMAD1 (Mothers Against Decapentaplegic Homolog 1, MAD Homolog 1, Mothers Against DPP Homolog 1, JV4-1, Mad-related Protein 1, SMAD Family Member 1, SMAD 1, hSMAD1, Transforming Growth Factor-beta-signaling Protein 1, BSP-1, BSP1, MADH1, MADR1) Pab Rb x Hu
S1014-51E Smad1 (Small Mothers Against Decapentaplegic Deleted in Pancreatic Carcinoma) Pab Rb x Hu
S1014-51F Smad1 (MADR1, Small Mothers Against Decapentaplegic Deleted in Pancreatic Carcinoma) Mab Rb x Hu
S1014-51G Smad1 (SMAD Family Member 1, SMAD-1, BSP1, BSP-1, Dwarfin A, DwfA, hSMAD1, hSMAD-1, JV41, JV4-1, MAD Mothers Against Decapentaplegic Homolog 1, Mothers Against Decapentaplegic Homolog 1, Mothers Against DPP Homolog 1, MADH1, Mad-related Protein 1, MADR1, Sma and Mad-related Protein 1, SMAD Mothers Against DPP Homolog 1 Drosophila, Spinal Muscular Atrophy Distal with Upper Limb Predominance, Transforming Growth Factor beta Signaling Protein 1, TGF beta Signaling Protein 1) Pab Rb x Hu
S1014-51H Smad1, phosphorylated (Ser465) (Small Mothers Against Decapentaplegic Deleted in Pancreatic Carcinoma) Pab Rb x Hu