Suc-Leu-Tyr-AMC CAS 94367-20-1

CAS Number

94367-20-1

Grade

Highly Purified

Molecular Formula

C29H33N3O8

Molecular Weight

551.6

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

-20°C

Fluorogenic substrate for measuring the chymotrypsin-like peptidase activity of the 20S proteasome. Fluorogenic substrate for calpain and papain. Peptide substrate for Ti protease from E. coli. This substrate is useful for inhibitor screening and kinetic analysis.

Synonyms

Suc-LY-AMC; Proteasome Substrate; Calpain Substrate; Papain Substrate

CAS Number

94367-20-1

Appearance

Supplied as a solid lyophilized powder.

Purity

>98% (TLC)

Excitation

Excitation: 360nm. Emission: 460nm.

Molecular Formula

C29H33N3O8

Molecular Weight

551.6

Sequence

N-Succinyl-Leu-Tyr-7-amido-4-methylcoumarin

Solubility

Soluble in DMSO or methanol.

Use

Add from DMSO stock directly to in vitro or in vivo assays at desired concentration. Typical concentrations range from 10-100uM.

Storage and Stability

Stable for at least 1 year after receipt when stored at -20°C.

References

1. Comparative specificity and kinetic studies on porcine calpain I and calpain II with naturally occurring peptides and synthetic fluorogenic substrates: T. Sasaki, et al.; J. Biol. Chem. 259, 12489 (1984). 2. Na+, K+-specific inhibition of protein and peptide hydrolyses by proteasomes from human hepatoma tissues: J.H. Seol, et al.; FEBS Lett. 247, 197 (1989). 3. Protease Ti from Escherichia coli requires ATP hydrolysis for protein breakdown but not for hydrolysis of small peptides: K.M. Woo, et al.; J. Biol. Chem. 264, 2088 (1989). 4. Ube2l3 gene expression is modulated by activation of the aryl hydrocarbon receptor: implications for p53 ubiquitination: O.D. Reyes-Hernandez, et al.; Biochem. Pharmacol. 80, 932 (2010).

USBio References

No references available

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226823 Suc-Leu-Tyr-AMC (Suc-LY-AMC, Proteasome Substrate, Calpain Substrate, Papain Substrate) CAS: 94367-20-1

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