MLF1, Recombinant, Human, aa1-268, His-Tag CAS

Grade

Purified

Accession Number

NP_071888

Molecular Weight

32.8

EU Commodity Code

30021019

Shipping Temp

Blue Ice

Storage Temp

-20°C

MLF1 (Myeloid leukemia factor 1) belongs to MLF family, and is a widely expressed negative regulator of cell cycle progression functioning upstream of the tumor suppressor p53. This protein interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. MLF1 normally functions in multi-potent progenitor cells, and its dysregulation may be somewhat responsible for leukemogenesis.

Source

Recombinant protein corresponding to aa1-268 of human MFL1, fused to His-tag at N-terminal expressed in E. coli.

Molecular Weight

~32.8kD

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MFRMLNSSFE DDPFFSESIL AHRENMRQMI RSFSEPFGRD LLSISDGRGR AHNRRGHNDG EDSLTHTDVS SFQTMDQMVS NMRNYMQKLE RNFGQLSVDP NGHSFCSSSV MTYSKIGDEP PKVFQASTQT RRAPGGIKET RKAMRDSDSG LEKMAIGHHI HDRAHVIKKS KNKKTGDEEV NQEFINMNES DAHAFDEEWQ SEVLKYKPGR HNLGNTRMRS VGHENPGSRE LKRREKPQQS PAIEHGRRSN VLGDKLHIKG SSVKSNKK

Storage and Stability

May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Source

Recombinant, E. coli

Purity

≥85% (SDS-PAGE)

Concentration

~0.5mg/ml

Form

Supplied as a liquid in 20mM Tris-HCl, pH 8.0, 5mM DTT, 200mM sodium chloride, 40% glycerol.

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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350078 MLF1, Recombinant, Human, aa1-268, His-Tag (Myeloid leukemia factor 1) CAS:

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