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350322 TCEAL7, Recombinant, Human, aa1-100, His-Tag (Transcription elongation factor A (SII)-like 7) CAS:

Specifications
References
Grade
Purified
Accession Number
NP_689491
Molecular Weight
14.8
EU Commodity Code
30021019
Shipping Temp
Blue Ice
Storage Temp
-20°C

TCEAL7 plays a role in the negative regulation of NF-kappa-B signaling at the basal level by modulating transcriptional activity of NF-kappa-B on its target gene promoters. It associates with cyclin D1 promoter containing Myc E-box sequence and transcriptionally represses cyclin D1 expression. This protein regulates telomerase reverse transcriptase expression and telomerase activity in both ALT (alternative lengthening of telomeres) and telomerase-positive cell lines.

Source
Recombinant protein corresponding to aa1-100 of human TCEAL7, fused to His-tag at N-terminal expressed in E. coli.
Molecular Weight
~14.8kD
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSHMQKPCK ENEGKPKCSV PKREEKRPYG EFERQQTEGN FRQRLLQSLE EFKEDIDYRH FKDEEMTREG DEMERCLEEI RGLRKKFRAL HSNHRHSRDR PYPI
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Source
Recombinant, E. coli
Purity
≥80% (SDS-PAGE)
Concentration
~0.5mg/ml
Form
Supplied as a liquid in 20mM Tris-HCl, pH 8.0, 0.2M sodium chloride, 2mM DTT, 50% glycerol.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Lafferty-Whyte,K., et al. (2010) Neoplasia 12(5), 405-414, 2. Rattan,R., et al. (2010) Oncogene 29 (9), 1362-1373.
USBio References
No references available
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