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370673 JMJD1C, Recombinant, Human, aa2274-2498, His-SUMO-Tag, Myc-Tag (Probable JmjC Domain-containing Histone Demethylation Protein 2C) CAS:

Specifications
References
Grade
Purified
Swiss Prot
Q15652
Molecular Weight
45.5
EU Commodity Code
30021019
Shipping Temp
Blue Ice
Storage Temp
-20°C

Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity).

Source
Partial recombinant protein corresponding to aa2274-2498 of human JMJD1C, fused to 10xHis-SUMO-Tag at N-terminal and Myc-Tag at C-terminal, expressed in E. coli.
Molecular Weight
~45.5kD
Amino Acid Sequence
MPARYEDLLKSLPLPEYCNPEGKFNLASHLPGFFVRPDLGPRLCSAYGVVAAKDHDIGTTNLHIEVSDVVNILVYVGIAKGNGILSKAGILKKFEEEDLDDILRKRLKDSSEIPGALWHIYAGKDVDKIREFLQKISKEQGLEVLPEHDPIRDQSWYVNKKLRQRLLEEYGVRTCTLIQFLGDAIVLPAGALHQVQNFHSCIQVTEDFVSPEHLVESFHLTQELR
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Source
Recombinant, E. coli
Purity
≥90% (SDS-PAGE)
Concentration
As Reported
Form
Supplied as a liquid in Tris, 50% glycerol.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Small Molecular Modulators of JMJD1C Preferentially Inhibit Growth of Leukemia Cells Xu X, et al,Livestock Science,July 4.
USBio References
No references available
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