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374321 Mug1, Recombinant, Mouse, aa700-910, His-Tag (Murinoglobulin-1) CAS:

Specifications
References
Grade
Purified
Swiss Prot
P28665
Molecular Weight
27
EU Commodity Code
30021019
Shipping Temp
Blue Ice
Storage Temp
-20°C

A proteinase activates the inhibitor by specific proteolysis in the bait region, which, by an unknown mechanism leads to reaction at the cysteinyl-glutamyl internal thiol ester site and to a conformational change, whereby the proteinase is trapped and/or covalently bound to the inhibitor. While in the tetrameric proteinase inhibitors steric inhibition is sufficiently strong, monomeric forms need a covalent linkage between the activated glutamyl residue of the original thiol ester and a terminal amino group of a lysine or another nucleophilic group on the proteinase, for inhibition to be effective.

Source
Recombinant protein corresponding to aa700-910 from mouse Mug1, fused to His-Tag at N-terminal, expressed in E. coli.
Molecular Weight
~27kD
Amino Acid Sequence
TPEISWSLRTTLSKRPEEPPRKDPSSNDPLTETIRKYFPETWVWDIVTVNSTGLAEVEMTVPDTITEWKAGALCLSNDTGLGLSSVVPLQAFKPFFVEVSLPYSVVRGEAFMLKATVMNYLPTSMQMSVQLEASPDFTAVPVGDDQDSYCLSANGRHTSSWLVTPKSLGNVNFSVSAEAQQSSEPCGSEVATVPETGRKDTVVKVLIVEPE
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Source
Recombinant, E. coli
Purity
≥90% (SDS-PAGE)
Concentration
As Reported
Form
Supplied as a liquid in Tris, 50% glycerol.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides. Bernhard O.K., Kapp E.A., Simpson R.J.J. Proteome Res. 6:987-995(2007).
USBio References
No references available
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