PDCD1, Recombinant, Human, aa21-170, His-SUMO-Tag CAS

Grade

Purified

Swiss Prot

Q15116

Molecular Weight

32.8

EU Commodity Code

30021019

Shipping Temp

Blue Ice

Storage Temp

-20°C

CD279

Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors.

Source

Recombinant protein corresponding to aa21-170 from human CD279, fused to His-SUMO-Tag at N-terminal expressed in E. coli.

Molecular Weight

~32.8kD

Amino Acid Sequence

PGWFLDSPDRPWNPPTFSPALLVVTEGDNATFTCSFSNTSESFVLNWYRMSPSNQTDKLAAFPEDRSQPGQDCRFRVTQLPNGRDFHMSVVRARRNDSGTYLCGAISLAPKAQIKESLRAELRVTERRAEVPTAHPSPSPRPAGQFQTLV

Storage and Stability

May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Source

Recombinant, E. coli

Purity

≥90% (SDS-PAGE)

Concentration

As Reported

Form

Supplied as a liquid in Tris, 50% glycerol.

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

References

1. Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.The role of the PD-1 pathway in autoimmunity and peripheral tolerance.Fife B.T., Pauken K.E.Ann. N. Y. Acad. Sci. 1217:45-59(2011).

USBio References

No references available

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374639 PDCD1, Recombinant, Human, aa21-170, His-SUMO-Tag (Programmed Cell Death Protein 1) CAS:

Grade

Swiss Prot

Molecular Weight

EU Commodity Code

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CD279

References

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