Technical Data
4-1 BB Receptor, Recombinant, Human (CD137, 4-1BB Ligand Receptor, TNFRSF9, CDw137, ILA, MGC2172, T-cell antigen 4-1BB homolog)
Molecular Biology Storage: -20CShipping: Blue Ice
4-1BB receptor (4-1BBR), also known as CD137, is a type I transmembrane glycoprotein and member of the tumor necrosis factor receptor superfamily, predominantly expressed by activated T cells, which acts as a receptor for 4-1BB ligand (4-1BBL). Interaction between CD137 and 4-1BBL, acts as a co-stimulatory signal for T cell activation and expansion, and is involved in the generation of cytotoxic T cells (Tc) and in the process of antigen presentation. CD137 also binds to the adaptor proteins TRAF1, 2 and 3 to act as a signal transducer of NF-kappaB activation.


Suitable for use in Functional Assays. Other applications not tested.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Endotoxin: 1EU/ug

Molecular Weight: 17.7kD (167 amino acid residues)

Biological Activity:
Determined by its inhibitory effect of the 4-1BBL mediated stimulation of IL-8 production by human PBMC. About 90% of inhibition was seen using a concentration of 1g for both CD137 and 4-1BBL.

Storage and Stability:
Lyophilized powder may be stored at -20C. Reconstitute with sterile buffer or ddH2O. Aliquot and store at -20C. Reconstituted product is stable for 6 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Source: E. coli
Purity: 98% (SDS PAGE and HPLC).
Concentration: ~0.1mg/ml
Form: Supplied in lyophilized powder. Reconstitute with 200ul sterile dH20.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.