Technical Data
0004-02F
4-1 BB Receptor, Recombinant, Human (CD137, 4-1BB Ligand Receptor, TNFRSF9, CDw137, ILA, MGC2172, T-cell antigen 4-1BB homolog)
20ug
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Technical Data |
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0004-02F |
4-1 BB Receptor, Recombinant, Human (CD137, 4-1BB Ligand Receptor, TNFRSF9, CDw137, ILA, MGC2172, T-cell antigen 4-1BB homolog) |
20ug |
| Growth Factors, Cytokines | Storage: -20°CShipping: Blue Ice |
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4-1BB receptor (4-1BBR), also known as CD137, is a type I transmembrane glycoprotein and member of the tumor necrosis factor receptor superfamily, predominantly expressed by activated T cells, which acts as a receptor for 4-1BB ligand (4-1BBL). Interaction between CD137 and 4-1BBL, acts as a co-stimulatory signal for T cell activation and expansion, and is involved in the generation of cytotoxic T cells (Tc) and in the process of antigen presentation. CD137 also binds to the adaptor proteins TRAF1, 2 and 3 to act as a signal transducer of NF-kappaB activation. Source: E.coli Applications: Suitable for use in Functional Assays. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Endotoxin: 1EU/ug Molecular Weight: 17.7kD (167 amino acid residues) Biological Activity: Determined by its inhibitory effect of the 4-1BBL mediated stimulation of IL-8 production by human PBMC. About 90% of inhibition was seen using a concentration of 1µg for both CD137 and 4-1BBL. Storage and Stability: Lyophilized powder may be stored at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot and store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. |
Source: E. coli Purity: 98% (SDS PAGE and HPLC). Concentration: ~0.1mg/ml Form: Supplied in lyophilized powder. Reconstitute with 200ul sterile dH20. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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