Technical Data
003022
AZD8055
10mg
Biochemicals Storage: RTShipping: RT
A potent, selective, and orally bioavailable ATP-competitive mTOR kinase inhibitor with an IC50 of 0.8 nM. It inhibits the phosphorylation of mTORC1 substrates p70S6K and 4E-BP1 as well as phosphorylation of the mTORC2 substrate AKT and downstream proteins. The rapamycin-resistant T37/46 phosphorylation sites on 4E-BP1 were fully inhibited by AZD8055, resulting in significant inhibition of cap-dependent translation. In vitro, AZD8055 potently inhibits proliferation and induces autophagy in H838 and A549 cells. In vivo, AZD8055 induces a dose-dependent pharmacodynamic effect on phosphorylated S6 and phosphorylated AKT at plasma concentrations leading to tumor growth inhibition.



CAS Number:
1009298-09-2

Molecular Formula:
C25H31N5O4

Molecular Weight:
465.54
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.
Chresta, C.M. et al.: Cancer Res., 70, 288 (2010); Sini, P. et al. Autophagy., 6 (2010); Marshall, G. et al.: Biochem. Soc. Trans., 39, 456 (2011);

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.