		Technical Data
004194	Bisindolylmaleimide XI Hydrochloride	2.5mg

Biochemicals

Storage: RTShipping: RT

Bisindolylmaleimide XI is a potent and selective cell-permeable protein kinase C (PKC) inhibitor. Studies reveal that inhibition of PKC by Bisindolylmaleimide XI and other similar PKC inhibitors has been associated with enhanced cardiac contractility and protection from heart failure. Bisindolylmaleimide XI has been shown to prevent T-cell activation and proliferation associated with chronic inflammatory responses in vivo.

Molecular Formula:
C28H29ClN4O2

Molecular Weight:
489.01

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.

Wilkinson, S.E. et al.: Biochem. J., 294, 335 (1993); Liu, Q., Chen, X. et al.: . Circ. Res. 105, 194 (2009); Birchall, A.M. et al.: J. Pharmacol. Exp. Ther., 268, 922 (1994);

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.