Technical Data
007102
Crenolanib
5mg
Biochemicals Storage: RTShipping: RT
Crenolanib is a tyrosine kinase inhibitor that acts by specifically inhibiting the receptor tyrosine kinases PDGFR and PDGFR . Crenolanib inhibits the activity of PDGFR D842V kinase and prevented the phosphorylation of wild type PDGFR . Crenolanib possesses potential antineoplastic activity. Crenolanib is believed to suppress PDGFR-related signal transduction pathways leading to the inhibition of tumor angiogenesis and tumor cell proliferation.

Form:
White to Off-White Solid

Melting Point:
217-220°C


Solubility:
DMSO, Methanol

CAS Number:
670220-88-9

Molecular Formula:
C26H29N5O2

Molecular Weight:
443.54
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.
Michael, M. et al.: Br. J. Cancer, 103, 1554 (2010); Lewis, N.L. et al.: J. Clin. Oncol., 27, 5262 (2009);

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.