Technical Data
021685
Thapsigargin
2.5mg
Biochemicals Storage: -20CShipping: Blue Ice
A widely used inhibitor of the ubiquitous sarco-endoplasmic reticulum Ca(2+)-ATPases in mammalian cells. It acts as a potent, cell-permeable, IP3-independent intracellular calcium releaser that blocks the transient increase in intracellular Ca2+ induced by angiostatin and endostatin. It induces apoptosis by disrupting intracellular free Ca2+ levels.

Form:
Off-White Solid

Melting Point:
84-90C


Solubility:
Chloroform

CAS Number:
67526-95-8

Molecular Formula:
C34H50O12

Molecular Weight:
650.75
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards:All products should be handled by qualified personnel only, trained in laboratory procedures.
Treiman, M. et al.: Trends Pharmacol. Sci., 19, 131 (1998); Korge, P. et al.: Eur. J. Biochem., 265, 273 (1999); Tsukamoto, A. Cell Biol. Int., 17, 969 (1993); Kutinova C.N. et al.: Cell Biol. Toxicol., 23, 337 (2007);

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.