		Technical Data
029106	CTNNB1 (Catenin beta-1, Beta-catenin, CTNNB, OK/SW-cl.35, PRO2286) (FITC)

Description:
Involved in the regulation of cell adhesion. The majority of beta-catenin is localized to the cell membrane and is part of E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton. Involved in signal transduction through the Wnt pathway. Nuclear beta-catenin it involved in transcriptional regulation by association with transcription factors of the TCF/LEF family.

Applications:
Suitable for use in ELISA and Western Blot. Other applications not tested.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. FITC conjugates are sensitive to light.

Type	Isotype	Clone	Grade
Pab	IgG		Purified

Size		Storage	Shipping	Source	Host
50ug		-20°C	Blue Ice	Human	Rabbit

Concentration:

As reported

Immunogen:

Recombinant corresponding to human Catenin beta-1.

Purity:

Purified by ammonium sulfate precipitation.

Form

Supplied as a liquid in PBS. Labeled with fluorescein isothiocyanate (FITC).

Specificity:

Recognizes human CTNNB1.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

1. "E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton." Huelsken J., Birchmeier W., Behrens J.J. Cell Biol. 127:2061-2069(1994).