Technical Data
029219
NIR2 (Membrane-associated Phosphatidylinositol Transfer Protein 1, Drosophila Retinal Degeneration B Homolog, Phosphatidylinositol Transfer Protein, Membrane-associated 1, PITPnm 1, Pyk2 N-terminal Domain-interacting Receptor 2, NIR-2, PITPNM1, DRES9, PIT
Description:
Regulates RHOA activity, and plays a role in cytoskeleton remodeling. Necessary for normal completion of cytokinesis. Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus. Binds phosphatidyl inositol phosphates (in vitro). May catalyze the transfer of phosphatidylinositol and phosphatidylcholine between membranes.Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus. Required for protein export from the endoplasmic reticulum and the Golgi. Binds calcium ions.

Applications:
Suitable for use in FLISA and Western Blot. Other applications not tested.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20C. Aliquots are stable for 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. FITC conjugates are sensitive to light.
TypeIsotypeCloneGrade
PabIgGPurified
SizeStorageShippingSourceHost
50ug-20CBlue IceHumanRabbit
Concentration:
As reported
Immunogen:
Recombinant corresponding to human NIR2.
Purity:
Purified by ammonium sulfate precipitation.
Form
Supplied as a liquid in PBS. Labeled with fluorescein isothiocyanate (FITC).
Specificity:
Recognizes human NIR2.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. "A mammalian homologue of the Drosophila retinal degeneration B gene: implications for the evolution of phototransduction mechanisms."Rubboli F., Bulfone A., Bogni S., Marchitiello A., Zollo M., Borsani G., Ballabio A., Banfi S.Genes Funct. 1:205-213 (1997). 2. "Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein."Lev S., Hernandez J., Martinez R., Chen A., Plowman G., Schlessinger J.Mol. Cell. Biol. 19:2278-2288 (1999). 3. "Chromosomal localization, genomic organization and evolution of the genes encoding human phosphatidylinositol transfer protein membrane-associated (PITPNM) 1, 2 and 3."Ocaka L., Spalluto C., Wilson D.I., Hunt D.M., Halford S.Cytogenet. Genome Res. 108:293-302 (2005).