		Technical Data
029220	NIR2 (Membrane-associated Phosphatidylinositol Transfer Protein 1, Drosophila Retinal Degeneration B Homolog, Phosphatidylinositol Transfer Protein, Membrane-associated 1, PITPnm 1, Pyk2 N-terminal Domain-interacting Receptor 2, NIR-2, PITPNM1, DRES9, PIT

Description:
Regulates RHOA activity, and plays a role in cytoskeleton remodeling. Necessary for normal completion of cytokinesis. Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus. Binds phosphatidyl inositol phosphates (in vitro). May catalyze the transfer of phosphatidylinositol and phosphatidylcholine between membranes.Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus. Required for protein export from the endoplasmic reticulum and the Golgi. Binds calcium ions.

Applications:
Suitable for use in ELISA and Western Blot. Other applications not tested.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Type	Isotype	Clone	Grade
Pab	IgG		Purified

Size		Storage	Shipping	Source	Host
50ug		-20°C	Blue Ice	Human	Rabbit

Concentration:

As reported

Immunogen:

Recombinant corresponding to human NIR2.

Purity:

Purified by ammonium sulfate precipitation.

Form

Supplied as a liquid in PBS. Labeled with Biotin.

Specificity:

Recognizes human NIR2.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

1. "A mammalian homologue of the Drosophila retinal degeneration B gene: implications for the evolution of phototransduction mechanisms."Rubboli F., Bulfone A., Bogni S., Marchitiello A., Zollo M., Borsani G., Ballabio A., Banfi S.Genes Funct. 1:205-213 (1997). 2. "Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein."Lev S., Hernandez J., Martinez R., Chen A., Plowman G., Schlessinger J.Mol. Cell. Biol. 19:2278-2288 (1999). 3. "Chromosomal localization, genomic organization and evolution of the genes encoding human phosphatidylinositol transfer protein membrane-associated (PITPNM) 1, 2 and 3."Ocaka L., Spalluto C., Wilson D.I., Hunt D.M., Halford S.Cytogenet. Genome Res. 108:293-302 (2005).