Technical Data
029371
SNX3 (Sorting Nexin-3, Protein SDP3) (HRP)
Description:
Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol-3-phosphate (PtdIns(P3)). Plays a role in protein transport between cellular compartments. Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G By similarity. Not involved in EGFR degradation.

Applications:
Suitable for use in ELISA and Western Blot. Other applications not tested.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Labeled with horseradish peroxidase (HRP). Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. HRP conjugates are sensitive to light.
TypeIsotypeCloneGrade
PabIgGPurified
SizeStorageShippingSourceHost
50ug-20°CBlue IceHumanRabbit
Concentration:
As reported
Immunogen:
Recombinant corresponding to human SNX3.
Purity:
Purified by ammonium sulfate precipitation.
Form
Supplied as a liquid in PBS. Labeled with horseradish peroxidase (HRP).
Specificity:
Recognizes human SNX3.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. "Identification of a family of sorting nexin molecules and characterization of their association with receptors." Haft C.R., de la Luz Sierra M., Barr V.A., Haft D.H., Taylor S.I. Mol. Cell. Biol. 18:7278-7287 (1998). 2. "SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P." Xu Y., Hortsman H., Seet L., Wong S.H., Hong W. Nat. Cell Biol. 3:658-666. 3. "Homo sapiens sorting nexin 3A (SNX 3A) mRNA." Hayama A., Uchida S., Sasaki S., Marumo F. 4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S. Nat. Genet. 36:40-45 (2004).