Technical Data
029519
JAM-A (Junctional Adhesion Molecule A, Junctional Adhesion Molecule 1, JAM-1, CD321, F11r, Jam1, Jcam, Jcam1)
Description:
Functional adhesion molecule A is found in endothelial and epithelial tight junctions and is involved in the inflammatory enlistment of mononuclear cells containing LFA-1. JAM-A is linked to atherogenesis, platelet activation, transmigration of leukocytes and angiogenesis. JAM-A is also found to be important in the development of many different organ systems, and is mostly expressed in the epithelial parts and the embryonic vasculature. JAM-A is indicated to play a role in epithelial permeability, inflammation and proliferation in the intestine, aiding in homeostasis.

Applications:
Suitable for use in Flow Cytometry, Immunoprecipitation and Immunocytochemistry. Other applications not tested.

Recommended Dilution:
Flow Cytometry: 1:1000
Optimal dilutions to be determined by the researcher.

Positive Control:
bEnd.3 cells

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
MabIgG2b,k13A203Affinity Purified
SizeStorageShippingSourceHost
10ul-20CBlue IceMouseRat
Concentration:
Not determined
Immunogen:
H5V murine heart capillary endothelial cells.
Purity:
Purified by Protein G affinity chromatography.
Form
Supplied as a liquid in PBS. No preservative added.
Specificity:
Recognizes mouse JAM-A.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Nava, P., et al. (2011). EMBO Rep. 12(4):314-320. 2. Laukoetter, M.G., et al. (2007). J Exp Med. 204(13):3067-3076. 3. Parris, J.J., et al. (2005). Dev Dyn. 233(4): 1517-1524. 4. Ostermann, G., et al. (2005). Arterioscler Thromb Vasc Biol. 25(4):729-735. 5. Martin-Padura, I., et al. (1998). J Cell Biol. 142(1):117-127. 6. Scheiermann, C., et al. (2007). Science. 318(5855): 1472-1475.