		Technical Data
029519	JAM-A (Junctional Adhesion Molecule A, Junctional Adhesion Molecule 1, JAM-1, CD321, F11r, Jam1, Jcam, Jcam1)

Description:
Functional adhesion molecule A is found in endothelial and epithelial tight junctions and is involved in the inflammatory enlistment of mononuclear cells containing LFA-1. JAM-A is linked to atherogenesis, platelet activation, transmigration of leukocytes and angiogenesis. JAM-A is also found to be important in the development of many different organ systems, and is mostly expressed in the epithelial parts and the embryonic vasculature. JAM-A is indicated to play a role in epithelial permeability, inflammation and proliferation in the intestine, aiding in homeostasis.

Applications:
Suitable for use in Flow Cytometry, Immunoprecipitation and Immunocytochemistry. Other applications not tested.

Recommended Dilution:
Flow Cytometry: 1:1000
Optimal dilutions to be determined by the researcher.

Positive Control:
bEnd.3 cells

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Type	Isotype	Clone	Grade
Mab	IgG2b,k	13A203	Affinity Purified

Size		Storage	Shipping	Source	Host
10ul		-20°C	Blue Ice	Mouse	Rat

Concentration:

As reported

Immunogen:

H5V murine heart capillary endothelial cells.

Purity:

Purified by Protein G affinity chromatography.

Form

Supplied as a liquid in PBS. No preservative added.

Specificity:

Recognizes mouse JAM-A.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

1. Nava, P., et al. (2011). EMBO Rep. 12(4):314-320. 2. Laukoetter, M.G., et al. (2007). J Exp Med. 204(13):3067-3076. 3. Parris, J.J., et al. (2005). Dev Dyn. 233(4): 1517-1524. 4. Ostermann, G., et al. (2005). Arterioscler Thromb Vasc Biol. 25(4):729-735. 5. Martin-Padura, I., et al. (1998). J Cell Biol. 142(1):117-127. 6. Scheiermann, C., et al. (2007). Science. 318(5855): 1472-1475.