Technical Data
029520
JAM-C (Junctional Adhesion Molecule C, JAM-2, Junctional Adhesion Molecule 3, JAM-3)
Description:
Junctional adhesion molecule C is an adhesion molecule found at endothelial intracellular junctions that plays a role in leukocyte transendothelial migration and other inflammatory events. JAM-C seems to be important in the pathophysiology of pancreatitis and therefore could be a promising clinical target. JAM-C expression has been shown to be increased when T lymphocytes are activated. Research has shown that controlling JAM-C may also be a way of controlling pathological angiogenesis.

Applications:
Suitable for use in Western Blot. Other applications not tested.

Recommended Dilution:
Western Blot: 0.05ug/ml
Optimal dilutions to be determined by the researcher.

Positive Control:
Human brain tissue lysate

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabAffinity Purified
SizeStorageShippingSourceHost
100ug-20CBlue IceHumanRabbit
Concentration:
~1mg/ml
Immunogen:
Synthetic linear peptide corresponding to the cytoplasmic domain of human JAM-C (KLH).
Purity:
Purified by immunoaffinity chromatography.
Form
Supplied as a liquid in 0.1M Tris-glycine, pH 7.4, 150mM sodium chloride, 0.05% sodium azide.
Specificity:
Recognizes human JAM-C. Species Crossreactivity: Mouse and rat. Species sequence homology: rhesus macaque and chimpanzee (100%).
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Rabquer, B.J., et al. (2010). J Immunol. 185(3): 1777-1785. 2. Immenschuh, S., et al. (2009). J Leukoc Biol. 85(5):796-803. 3. Bradfield, P.F., et al. (2007). Blood. 110(7): 2545-2555. 4. Vonlaufen, A., et al. (2006). J Pathol. 209(4): 540-548. 5. Lamagna, C., et al. (2005). Cancer Res. 65: 5703-5710.