Technical Data
030382
Prostate Specific Antigen (Prostate-specific Antigen, PSA, APS, Gamma-seminoprotein, Kallikrein-3, KLK3, hK3, KLK2A1, P-30 Antigen, Seminin, Semenogelase)
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Technical Data |
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030382 |
Prostate Specific Antigen (Prostate-specific Antigen, PSA, APS, Gamma-seminoprotein, Kallikrein-3, KLK3, hK3, KLK2A1, P-30 Antigen, Seminin, Semenogelase) |
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Description: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. Applications: ELISA: Suggested dilution 1:10000. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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