Technical Data
030750
AGT, NT (SERPINA8, Angiotensinogen, Serpin A8, Angiotensin-1, Angiotensin I, Angiotensin-2, Angiotensin II, Angiotensin-3, Angiotensin III, Des-Asp[1]-angiotensin II)
Description:
The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.

Applications:
Suitable for use in Western Blot, ELISA.

Recommended Dilution:
ELISA: 1:1,000
Western Blot: 1:100~1000

Storage and Stability:
May be stored at 4C for short-term only. For long-term storage, store at -20C. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
TypeIsotypeCloneGrade
MabIgG1656CT5.8.4Affinity Purified
SizeStorageShippingSourceHost
200ul-20CBlue IceHumanMouse
Concentration:
As reported
Immunogen:
AGT Mab is generated from mouses immunized with a KLH conjugated synthetic peptide selected from human AGT.
Purity:
Purified by Protein G affinity chromatography.
Form
Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide.
Specificity:
Human
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
Desong, Liu., et al. J Renin Angiotensin Aldosterone Syst 11(4):248-255(2010)
Procopciuc, L.M., et al. Eur. J. Intern. Med. 21(5):414-418(2010)
Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010)
Hajjar, I., et al. J Am Geriatr Soc 58(6):1035-1042(2010)
Kiec-Wilk, B., et al. Prz. Lek. 67(3):151-156(2010)