Technical Data
030889
CSF1R (CSF1R, FMS, Macrophage colony-stimulating factor 1 receptor, CSF-1 receptor, Proto-oncogene c-Fms, CD_antigen=CD115, Flags: Precursor)
Description:
The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. [provided by RefSeq].

Applications:
Suitable for use in Western Blot, ELISA.

Recommended Dilution:
ELISA: 1:1000
Western Blot: 1:1000

Storage and Stability:
May be stored at 4C for short-term only. For long-term storage, store at -20C. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
TypeIsotypeCloneGrade
Mab177CT7.1.1Ascites
SizeStorageShippingSourceHost
100ul-20CBlue IceHumanMouse
Concentration:
As reported
Immunogen:
CSF1R Mab was raised using purified His-tagged recombinant human CSF1R.
Purity:
Ascites
Form
Supplied as a liquid, crude ascites with 0.09% sodium azide.
Specificity:
Human
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
Shin, E.K., et al. Hum. Genet. 128(3):293-302(2010)
Wei, S., et al. J. Leukoc. Biol. 88(3):495-505(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010)
Paniagua, R.T., et al. Arthritis Res. Ther. 12 (1), R32 (2010)
Wooten, E.C., et al. PLoS ONE 5 (1), E8830 (2010)