Technical Data
030909
DDR2 (DDR2, NTRKR3, TKT, TYRO10, Discoidin domain-containing receptor 2, CD167 antigen-like family member B, Discoidin domain-containing receptor tyrosine kinase 2, Neurotrophic tyrosine kinase, receptor-related 3, Receptor protein-tyrosine kinase TKT, Ty
Description:
Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein. [provided by RefSeq].

Applications:
Suitable for use in Western Blot, ELISA.

Recommended Dilution:
ELISA: 1:1,000
Western Blot: 1:100~1600

Storage and Stability:
May be stored at 4C for short-term only. For long-term storage, store at -20C. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
TypeIsotypeCloneGrade
MabIgG1484CT5.5.4Ascites
SizeStorageShippingSourceHost
100ul-20CBlue IceHumanMouse
Concentration:
As reported
Immunogen:
Purified His-tagged DDR2 protein (fragment).
Purity:
Ascites
Form
Supplied as a liquid, crude ascites with 0.09% sodium azide.
Specificity:
Human
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010)
Ali, B.R., et al. Hum. Mol. Genet. 19(11):2239-2250(2010)
Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010)
Ehret, G.B., et al. Eur. J. Hum. Genet. 17(12):1650-1657(2009)
Su, J., et al. Mol. Cell. Biochem. 330 (1-2), 141-152 (2009)