Technical Data
030961
FGA, NT (FGA, Fibrinogen alpha chain, Fibrinopeptide A)
Description:
The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in two isoforms which vary in the carboxy-terminus. [provided by RefSeq].

Applications:
Suitable for use in Western Blot, ELISA.

Recommended Dilution:
ELISA: 1:1,000
Western Blot: 1:100~500

Storage and Stability:
May be stored at 4C for short-term only. For long-term storage, store at -20C. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
TypeIsotypeCloneGrade
MabIgM471CT12.1.2Purified
SizeStorageShippingSourceHost
200ul-20CBlue IceHumanMouse
Concentration:
As reported
Immunogen:
FGA Mab is generated from mice immunized with a KLH conjugated synthetic peptide selected from the N-term region of human FGA.
Purity:
Purified by ammonium sulfate precipitation.
Form
Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide.
Specificity:
Human, mouse
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
Bahadori, B., et al. Thromb. Res. 126(4):350-352(2010)
Chen, Z., et al. Hum. Genet. 128(4):443-452(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Gu, W.P., et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 27(3):286-289(2010)
Ban, H.J., et al. BMC Genet. 11, 26 (2010)