Technical Data
031161
Notch3, CT (Notch homolog 3, Drosophila, hN3, CASIL, CADASIL)
Description:
This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq].

Applications:
Suitable for use in Western Blot, ELISA.

Recommended Dilution:
ELISA: 1:1,000
Western Blot: 1:100~1600

Storage and Stability:
May be stored at 4C for short-term only. For long-term storage, store at -20C. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
TypeIsotypeCloneGrade
MabIgG1487CT6.9.2Ascites
SizeStorageShippingSourceHost
100ul-20CBlue IceHumanMouse
Concentration:
As reported
Immunogen:
NOTCH3 Mab is generated from mice immunized with a KLH conjugated synthetic peptide selected from the C-term region of human NOTCH3.
Purity:
Ascites
Form
Supplied as a liquid, crude ascites with 0.09% sodium azide.
Specificity:
Human
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
Liu, H., et al. Circ. Res. 107(7):860-870(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Menon, S., et al. Cephalalgia (2010) In press
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010)
Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010)