Technical Data
031293
TLE1, ID (TLE1, Transducin-like enhancer protein 1, E(Sp1) homolog, Enhancer of split groucho-like protein 1)
Description:
Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.

Applications:
Suitable for use in Western Blot, ELISA.

Recommended Dilution:
ELISA: 1:1,000
Western Blot: 1:100~250

Storage and Stability:
May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
TypeIsotypeCloneGrade
MabIgG1381CT18.5.1Affinity Purified
SizeStorageShippingSourceHost
100ug-20°CBlue IceHumanMouse
Concentration:
0.25mg/ml
Immunogen:
TLE1 Mab is generated from mouses immunized with a KLH conjugated synthetic peptide selected from the Central region of human TLE1.
Purity:
Purified by Protein G affinity chromatography.
Form
Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide.
Specificity:
Human
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010)
Carvalho, L.R., et al. Mol. Endocrinol. 24(4):754-765(2010)
Ali, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 107(9):4165-4169(2010)
Jagdis, A., et al. Am. J. Surg. Pathol. 33(12):1743-1751(2009)
Buscarlet, M., et al. PLoS ONE 4 (12), E8107 (2009)