Technical Data
ACCN4, NT (ASIC4, ACCN4, Acid-sensing ion channel 4, Amiloride-sensitive cation channel 4, Amiloride-sensitive cation channel 4, pituitary)
This gene belongs to the superfamily of acid-sensing ion channels, which are proton-gated, amiloride-sensitive sodium channels. These channels have been implicated in synaptic transmission, pain perception as well as mechanoperception. This gene is predominantly expressed in the pituitary gland, and was considered a candidate for paroxysmal dystonic choreoathetosis (PDC), a movement disorder, however, no correlation was found between mutations in this gene and PDC. Alternative splicing at this locus results in two transcript variants encoding different isoforms.

Suitable for use in Western Blot, ELISA

Recommended Dilution:
ELISA: 1:1,000
Western Blot: 1:100-500

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
PabIgGAffinity Purified
200ul-20CBlue IceHumanRabbit
As reported
ACCN4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 22-52 amino acids from the N-terminal region of human ACCN4.
Purified by Protein A affinity chromatography.
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
Donier, E., et al. Eur. J. Neurosci. 28(1):74-86(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Hillier, L.W., et al. Nature 434(7034):724-731(2005)
Grunder, S., et al. Eur. J. Hum. Genet. 9(9):672-676(2001)
Grunder, S., et al. Neuroreport 11(8):1607-1611(2000)