Technical Data
031561
ACSL4, NT (ACSL4, ACS4, FACL4, LACS4, Long-chain-fatty-acid-CoA ligase 4, Long-chain acyl-CoA synthetase 4)
Description:
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the mental retardation or Alport syndrome. Alternative splicing of this gene generates 2 transcript variants.

Applications:
Suitable for use in Western Blot, ELISA

Recommended Dilution:
ELISA: 1:1,000
Western Blot: 1:100-500

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
200ul-20CBlue IceHumanRabbit
Concentration:
As reported
Immunogen:
ACSL4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 27-56 amino acids from the N-terminal region of human ACSL4.
Purity:
Purified by Protein A affinity chromatography.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity:
Human
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
Bosker, F.J., et al. Mol. Psychiatry (2010) In press :
Zhang, Y., et al. Hum. Mol. Genet. 18(20):3894-3905(2009)
Zeman, M., et al. Tohoku J. Exp. Med. 217(4):287-293(2009)
An, C., et al. Neurosci. Lett. 441(2):197-200(2008)
Hu, C., et al. Cancer Biol. Ther. 7(1):131-134(2008)