Technical Data
031602
ADAM17, NT (ADAM17, CSVP, TACE, Disintegrin and metalloproteinase domain-containing protein 17, Snake venom-like protease, TNF-alpha convertase, TNF-alpha-converting enzyme, CD156b)
Description:
ADAM17 is a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. ADAM17 functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway.

Applications:
Suitable for use in Western Blot, Flow Cytometry, ELISA

Recommended Dilution:
ELISA: 1:1,000
Western Blot: 1:50-100
Flow Cytometry: 1:10-50

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
200ul-20CBlue IceHumanRabbit
Concentration:
As reported
Immunogen:
ADAM17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 202~232 amino acids from the N-terminal region of human ADAM17.
Purity:
Purified by peptide immunoaffinity chromatography.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity:
Human
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
Tellier,E., J. Cell. Physiol. 214 (3), 687-693 (2008)
Takamune,Y., Biochem. Biophys. Res. Commun. 365 (2), 393-398 (2008)