Technical Data
031747
AKR1D1, ID (AKR1D1, SRD5B1, 3-oxo-5-beta-steroid 4-dehydrogenase, Aldo-keto reductase family 1 member D1, Delta(4)-3-ketosteroid 5-beta-reductase, Delta(4)-3-oxosteroid 5-beta-reductase)
Description:
The enzyme encoded by this gene is responsible for the catalysis of the 5-beta-reduction of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure. Deficiency of this enzyme may contribute to hepatic dysfunction. Three transcript variants encoding different isoforms have been found for this gene. Other variants may be present, but their full-length natures have not been determined yet.

Applications:
Suitable for use in Western Blot, ELISA

Recommended Dilution:
ELISA: 1:1,000
Western Blot: 1:100-500

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
200ul-20CBlue IceHumanRabbit
Concentration:
As reported
Immunogen:
AKR1D1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 110-139 amino acids from the Central region of human AKR1D1.
Purity:
Purified by Protein A affinity chromatography.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity:
Human
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
Steen, N.E., et al. Prog. Neuropsychopharmacol. Biol. Psychiatry (2010) In press :
Drury, J.E., et al. J. Biol. Chem. 285(32):24529-24537(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Ueki, I., et al. J. Gastroenterol. Hepatol. 24(5):776-785(2009)
Panagopoulos, I., et al. Oncol. Rep. 21(3):615-624(2009)