Technical Data
031872
ANGPT1, CT (ANGPT1, KIAA0003, Angiopoietin-1)
Description:
Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart.

Applications:
Suitable for use in Western Blot. Other applications have not been tested.

Recommended Dilutions:
Western Blot: 1:1000
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
200ul-20CBlue IceHumanRabbit
Concentration:
As Reported
Immunogen:
Synthetic peptide corresponding to a portion of amino acids within aa374-402 from the C-terminal region of human ANGPT, conjugated to KLH (NP_001137). Cellular Localization: Secreted. Species Sequence Homology: mouse, bovine and porcine
Purity:
Purified by Protein A affinity chromatography.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity:
Recognizes human ANGPT1.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
Fang, X., et al. J. Biol. Chem. 285(34):26211-26222(2010) Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010) Choe, J.Y., et al. Joint Bone Spine 77(4):340-344(2010) Roberts, K.E., et al. Gastroenterology 139(1):130-139(2010) Chen, J., et al. Hum. Mol. Genet. 19(12):2524-2533(2010)