Technical Data
032031
ARHB, ID (RHOB, ARH6, ARHB, Rho-related GTP-binding protein RhoB, Rho cDNA clone 6)
Description:
ARHB mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development.

Applications:
Suitable for use in Western Blot, Immunohistochemistry, ELISA

Recommended Dilution:
ELISA: 1:1,000
Western Blot: 1:50-100
Immunohistochemistry: 1:10-50

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGPurified
SizeStorageShippingSourceHost
200ul-20CBlue IceHumanRabbit
Concentration:
As reported
Immunogen:
ARHB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 103-137 amino acids from the Central region of human ARHB.
Purity:
Purified by saturated ammonium sulfate precipitation followed by dialysis against PBS.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity:
Human
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
Adly, M.A., et al. J. Cutan. Pathol. 37(7):751-757(2010)
Connolly, E.C., et al. Mol. Cancer Res. 8(5):691-700(2010)
Zintzaras, E., et al. Am. J. Epidemiol. 171(8):851-858(2010)
Kim, C.H., et al. Biochem. Biophys. Res. Commun. 391(2):1182-1186(2010)
Takefuji, M., et al. J. Hum. Genet. 55(1):42-49(2010)