Technical Data
032881
C2, NT (C2, Complement C2, C3/C5 convertase, Complement C2b fragment, Complement C2a fragment)
Description:
Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.

Applications:
Suitable for use in Western Blot. Other applications have not been tested.

Recommended Dilution:
Western Blot: 1:1000
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
200ul-20CBlue IceHumanRabbit
Concentration:
As reported
Immunogen:
Synthetic peptide corresponding to aa147-176 from the N-terminal region of human C2 (NP_000054), conjugated to KLH.
Purity:
Purified by Protein A affinity chromatography.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity:
Recognizes human C2. Species crossreactivity: hamster
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Hu, M., et al. Pharmacogenet. Genomics 20(10):634-637(2010) 2. Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) 3. Liu, X., et al. Retina (Philadelphia, Pa.) 30(8):1177-1184(2010) 4. Han, S., et al. Hum. Immunol. 71(7):727-730(2010) 5. Ishii, Y., et al. J. Immunol. 151(1):170-174(1993)