Technical Data
033569
CDC2 (CDK1), NT (V-abl Abelson murine leukemia viral oncogene homolog 1, ABL1,)
Description:
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Transcript Variant: This variant (1) encodes the full length isoform.

Applications:
Suitable for use in Western Blot, ELISA

Recommended Dilution:
ELISA1:1,000
Western blotting 1:50-100

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
200ul-20CBlue IceHumanRabbit
Concentration:
As reported
Immunogen:
CDC2 (CDK1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide corresponding to amino acid residues surrounding S39 of human CDK1.
Purity:
Purified by peptide immunoaffinity chromatography.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity:
Human
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
Kramer, A., et al., Nat. Cell Biol. 6(9):884-891 (2004).
Dai, X., et al., J. Invest. Dermatol. 122(6):1356-1364 (2004).
Litvak, V., et al., Mol. Cell 14(3):319-330 (2004).
Shapira, M., et al., Cancer 100(8):1615-1621 (2004).
Chow, J.P., et al., J. Biol. Chem. 278(42):40815-40828 (2003).