Technical Data
033626
CDH19, CT (CDH19, CDH7L2, Cadherin-19)
Description:
This gene is a type II classical cadherin from the cadherin superfamily and one of three cadherin 7-like genes located in a cluster on chromosome 18. The encoded membrane protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Since disturbance of intracellular adhesion is a prerequisite for invasion and metastasis of tumor cells, cadherins are considered prime candidates for tumor suppressor genes.

Applications:
Suitable for use in Western Blot, Immunohistochemistry, ELISA

Recommended Dilution:
ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:10-50

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
200ul-20CBlue IceHumanRabbit
Concentration:
As reported
Immunogen:
CDH19 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 612-640 amino acids from the C-terminal region of human CDH19.
Purity:
Purified by Protein A affinity chromatography.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity:
Human
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
Need, A.C., et al. Hum. Mol. Genet. 18(23):4650-4661(2009)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
Kools, P., et al. Genomics 68(3):283-295(2000)
Shimoyama, Y., et al. Biochem. J. 349 (PT 1), 159-167 (2000) :
Kremmidiotis, G., et al. Genomics 49(3):467-471(1998)