Technical Data
033962
CLDN2, CT (Y195) (CLDN2, Claudin-2, SP82)
Description:
This gene product belongs to the claudin protein family whose members have been identified as major integral membrane proteins localized exclusively at tight junctions. Claudins are expressed in an organ-specific manner and regulate tissue-specific physiologic properties of tight junctions. This protein is expressed in the intestine. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene.

Applications:
Suitable for use in Western Blot, Immunohistochemistry and Flow Cytometry. Other applications have not been tested.

Recommended Dilution:
Western Blot: 1:1000
Immunohistochemistry: 1:10-1:50
Flow Cytometry: 1:10-1:50
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
200ul-20CBlue IceHumanRabbit
Concentration:
As reported
Immunogen:
Synthetic peptide corresponding to a portion of amino acids within aa174-201 from the C-terminal region of human CLDN2, conjugated with KLH.
Purity:
Purified by Protein A affinity chromatography.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity:
Recognizes human CLDN2.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Smith, A.J., et al. J. Acquir. Immune Defic. Syndr. 55(3):306-315(2010) 2. Kojima, F., et al. Oncol. Rep. 23(4):927-931(2010) 3. Szakal, D.N., et al. Virchows Arch. 456(3):245-250(2010) 4. Buchert, M., et al. Proc. Natl. Acad. Sci. U.S.A. 107(6):2628-2633(2010) 5. Mankertz, J., et al. Cell Tissue Res. 336(1):67-77(2009)