Technical Data
034084
COL18A1, ID (COL18A1, Collagen alpha-1(XVIII) chain, Endostatin)
Description:
COL18A1 is the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. The proteolytically produced C-terminal fragment of type XVIII collagen is endostatin, a potent antiangiogenic protein. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure.

Applications:
Suitable for use in Western Blot, Immunohistochemistry, ELISA

Recommended Dilution:
ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:50-100

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
200ul-20CBlue IceHumanRabbit
Concentration:
As reported
Immunogen:
COL18A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1314-1343 amino acids from the Central region of human COL18A1.
Purity:
Purified by Protein A affinity chromatography.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity:
Human, mouse
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
Hamano, Y., et al. J. Am. Soc. Nephrol. 21(9):1445-1455(2010)
Roberts, K.E., et al. Gastroenterology 139(1):130-139(2010)
Lee, K.S., et al. Tumour Biol. 31(3):165-170(2010)
Faye, C., et al. Biochem. J. 427(3):467-475(2010)
Polikarpova, S.B., et al. Bull. Exp. Biol. Med. 148(4):634-637(2009)